王国华

发布者:陈静2发布时间:2020-06-24浏览次数:10

                副研究员,硕士生导师,南通大学创新创业导师


个人简历:

王国华,硕士生导师,复旦大学博士,美国匹兹堡大学博士后,哈佛大学短期访问学者,南通大学创新创业导师。已先后入选江苏省“双创计划”人才,江苏省“333”工程培养对象,江苏省高校“青蓝工程”中青年学术带头人,江苏省第十三批“六大人才高峰”高层次人才,江苏省优秀留学回国人员,上海市优秀博士毕业生,南通市第五期“226”第二层次培养对象,南通大学“创新人才基金”资助对象。现任担任国际脑血流代谢协会青年委员(ISCBFM Young Investigator Committee),Brain大会执委会委员(Member of the Program Committee for BRAIN conference),中华医学会航海医学分会青年委员会委员、航海疾病专业委员会委员,中国研究型医院学会神经再生与修复专业委员会青年委员会常务委员,中国康复技术转化及发展促进会精准医学与肿瘤康复专业委员会常务委员,江苏省卒中学会卒中基础与转化医学专业委员会常务委员等。

5年来,以第一作者或通讯作者发表SCI论文12篇,单篇最高影响因子9.809,累计影响因子超60,他引达433次。作为项目负责人,先后主持国家自然科学2项,省部级项目3项,市厅级重点项目2项。作为第一申请人,荣获第二届江苏省科协青年会员创新创业大赛一等奖1项,省级三等奖2项以及南通市级科技进步二等奖1项。辅导研究生4次在“创青春”、“互联网+”大赛中获得省级二等奖。多次在本学科重要国际会议上,做口头汇报或壁报交流,连续两届荣获国际脑血流代谢协会议“Young Investigator Travel Bursary Award”。另外还担任多种J Cereb Blood Flow Metab, J Neurotrauma, Cellular and Molecular Neurobiology, Journal of Cancer, Experimental neurology, NeuroscienceCNS NEUROSCIENCE & THERAPEUTICS, Austin Journal of Cerebrovascular Disease & StrokeBrain Conference, International Stroke Conference的审稿人。参与编写《神经生物学》等教材3部,主持完成研究生精品建设课程1项。累计申请国家发明专利14项,其中4项已经获授权,横向合作科研经费累计超100万元。

 

研究领域:

脑损伤及神经保护;肿瘤炎症微环境调控。

 

联系方式:

wgh@ntu.edu.cn

 

代表性论文(第一或通讯作者):

  1. Xiaoyu Yuan, Qianqian Luo, Lihua Shen, Jin Chen, Deqiang Gan, Yechao Sun, Lingzhi Ding, Guohua Wang*. Hypoxic Preconditioning Enhances the Differentiation of Bone Marrow Stromal Cells into Mature Oligodendrocytes via the mTOR/HIF-1α/VEGF Pathway in Traumatic Brain Injury. Brain Behav, 2020 May 30; e01675. doi: 10.1002/brb3.1675.

  2. Qianqian Luo, Jianan Hu, Guang Yang, Xiaoyu Yuan, Zhongping Chen, Dan Wang, Yapeng Lu, Li Zhu*, Guohua Wang*. Fasting Increases Iron Export by Modulating Ferroportin 1 Expression through the Ghrelin/GHSR1α/MAPK Pathway in the Liver. Biol Trace Elem Res, 2020 Mar 25. doi: 10.1007/s12011-020-02114-x.

  3. Wang G*#, Ding L#, Gao C#, Zhang N, Gan D, Sun Y, Xu L, Luo Q, Jiang Z*. Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice. Neuropharmacology, 2019, 146:39-49.

  4. Chunyi Gao, Xiaoyu Yuan, Zhenglin Jiang*, Deqiang Gan, Lingzhi Ding, Yechao Sun, Jiamin Zhou, Lihua Xu, Yifei Liu, Guohua Wang*. Regulation of AKT phosphorylation by GSK3β and PTEN to control chemoresistance in breast cancer. Breast Cancer Research and Treatment, 2019, 176(2):291-301.

  5. Wu H, Li J, Chen J, Yin Y, Da P, Chen Q, Zhang Z, Wang J, Wang G*, Qiu X*. Highlight article: Efficacy of radiation exposure in laryngeal squamous cell carcinoma is mediated by the LAMP3/LAMC2/tenascin-C pathway. Exp Biol Med, 2019 Oct; 244(13):1070-1080.

  6. Luo Q#, Ding L#, Zhang N#, Jiang Z, Gao C, Xue L, Peng B, Wang G*. A stable and easily reproducible model of focal white matter demyelination. J Neurosci Methods. 2018, 307:230-239.

  7. Jin Chen#, Yuanyuan Yang#, Lihua Shen*, Wensen Ding, Xiang Chen, Erbing Wu, Kefu Cai, Guohua Wang*. Hypoxic Preconditioning Augments the Therapeutic Efficacy of Bone Marrow Stromal Cells in a Rat Ischemic Stroke Model. CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017.8, 37(6): 1115-1129.

  8. Wang G, Shi Y, Jiang X, Leak RK, Hu X, Wu Y, Pu H, Li WW, Tang B, Wang Y, Gao Y, Bennett MVL*, Chen J*. Histone deacetylase inhibition prevents white matter injury by modulating microglia/macrophage polarization through GSK3β/PTEN/Akt axis. Proc Natl Acad Sci U S A. 2015, 112(9):2853-2858.

  9. Wang G, Zhang J, Hu X, Zhang L, Mao L, Jiang X, Liou AK, Leak RK, Gao Y, Chen J*. Microglia/macrophage polarization dynamics in white matter after traumatic brain injury. J Cereb Blood Flow Metab. 2013 Dec;33(12):1864-74.

Wang GH, Jiang X, Pu H, Zhang W, An C, Hu X, Liou AK, Leak RK, Gao Y, Chen J*. Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway. Neurotherapeutics, 2013, 10(1):124-142.