吴小波,生物物理学博士,教授,硕士生导师。
2006年至2012年先后在陕西师范大学神经生物学和生物物理学专业学习,获博士学位。同年进入南通大学航海医学研究所工作,主要从事慢性疼痛和瘙痒的神经机制研究。2017年至2019年在美国纽约州立大学上州医科大学精神与行为学系从事博士后研究。近年来先后发表SCI论文20余篇,包括Journal of Neuroscience, Neuropsychopharmacology, Molecular pain等国际权威期刊。主持国家自然科学基金项目2项,江苏省高校自然科学基金面上项目1项,主要参与完成10余项国家级科研项目;且先后主持完成多项企业合作项目。兼任中国生理学会疼痛转化研究专业委员会委员,同时担任Nature Communication, BMC Medicine, Brain Behavior and Immunity, Pharmacological Research, Journal of Neurochemistry, Journal of Pain等国际著名SCI杂志审稿人。
主要研究方向:疼痛和痒觉的神经环路;疼痛、抑郁共病的细胞和分子机制;新型神经电刺激器的研发。
联系方式:xbwu1983@ntu.edu.cn
近期代表性论著:
1.Zhang PF, You WY, Gao YJ*, Wu XB*, Activation of pyramidal neurons in the infralimbic cortex alleviates LPS-induced depressive-like behavior in mice. Brain Research Bulletin, 2024, 214:111008 (通讯作者)
2.Wu XB*, Zhu Q, Gao MH, Yan SX, Gu PY, Zhang PF, Xu ML, Gao YJ*,Excitatory projections from the prefrontal cortex to nucleus accumbens core D1-MSNs and κ opioid receptor modulate itch-related scratching behaviors. Journal of Neruoscience, 2023, 43(8):1334-1347. (第一作者和共同通讯作者)
3.Wu XB*, Zhu Q, Gao YJ*, CCL2/CCR2 contributes to the altered excitatory-inhibitory synaptic balance in the nucleus accumbens shell following peripheral nerve injury-induced neuropathic pain. Neuroscience Bulletin, 2021, 37(7):921-933. (第一作者和共同通讯作者)
4.Wu XB, He LN, Jiang BC, Wang X, Lu Y, Gao YJ, Increased CXCL13 and CXCR5 in anterior cingulate cortex contributes to neuropathic pain-related conditioned place aversion. Neuroscience Bulletin, 2019, 35(4):613-623.
5.Wu XB, Jing PB, Zhang ZJ, Cao DL, Gao MH, Jiang BC, Gao YJ*. Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. Neuropsychopharmacology, 2018, 43(11): 2320-2330.
6.Wu XB, He LN, Jiang BC, Shi H, Bai XQ, Zhang WW, Gao YJ*. Spinal CXCL9 and CXCL11 are not involved in neuropathic pain despite an upregulation in the spinal cord following spinal nerve injury. Molecular pain, 2018, 14: 1-12.
7.Jiang BC #, He LN #, Wu XB #, Shi H, Zhang WW, Zhang ZJ, Cao DL, Li CH, Gu J, Gao YJ* Promoted interaction of C/EBP with demethylated Cxcr3 gene promoter contributes to neuropathic pain in mice. Journal of Neuroscience, 2017, 37 (3) 685-700. (Co-first)
8.Zhang Q, Zhu MD, Cao DL, Bai XQ, Gao YJ, Wu XB*. Chemokine CXCL13 activates p38 MAPK in the trigeminal ganglion after infraorbital nerve injury. Inflammation, 2017, 40(3): 762-769.(通讯作者)