吴小梅

发布者:陈静2发布时间:2020-06-10浏览次数:12

                                          


个人简介:

吴小梅,女,博士,副教授,硕士生导师。2006年获南通大学生物化学硕士学位,2011年获香港中文大学生理学博士学位,2015-2016年在美国佐治亚医学院进行两年博士后研究。从事脑缺血损伤和帕金森病的发生机制及防治研究近20年,在SCI收录的期刊上发表论文20多篇,包括Redox Biology, British Journal of  Pharmacology, Hepatology等国际权威期刊,发表的论文受到同行广泛引用。主持和参加了省厅级以上课题10项,现主持在研国家自然科学基金1项;入选江苏省卒中基础与转化专委会委员、南通大学优秀教育工作者;担任多个国际专业杂志的审稿专家。

主要研究方向:

脑缺血缺氧损伤的干预措施;帕金森病发生的分子机制;中枢神经系统突触囊泡循环的调节。

联系方式:

电话:0513-55003378  邮箱: wuxmsu@ntu.edu.cn 

代表性成果:

  1. Jianyou Su, Meng Wang, Yaohua Yan, Shaoqing Ju, Jian ChenXiaomei Wu*. Increased REDD1 facilitates neuronal damage after subarachnoid hemorrhage. Neurochemistry International. 2019, 128: 14-20.

  2. Yu-Fu Zhou#, Xiao-Mei Wu#, Gan Zhou, Ming-dao Mu, Fa-Li Zhang, Fe-Mi Li, Christopher Qian, Fang Du, Wing-Ho Yung, Zhong-Ming Qian, Ya Ke. Cystathionine β-synthase is required for body iron homeostasis. Hepatology. 2018, 67(1): 21-35.

  3. Xiao-Mei Wu, Christopher Qian, Yu-Fu Zhou, Yick-Chun Yan, Qian-Qian Luo, Wing-Ho Yung, Fa-Li Zhang, Li-Rong Jiang, Zhong Ming Qian, Ya Ke. Bi-directionally protective communication between neurons and astrocytes under ischemia. Redox Biology. 2017, 13: 20-31.

  4. Xiao-Mei Wu, Yong Liu, Zhong-Ming Qian, Qian-Qian Luo, Ya Ke. CX3CL1/CX3CR1 Axis Plays a Key Role in Ischemia-Induced Oligodendrocyte Injury via p38MAPK Signaling Pathway. Molecular Neurobiology. 2016, 53: 4010-4018.

  5. Lin Li#, Xiaomei Wu#, Hai-Yuan Yue, Yong-Chuan Zhu, Jianhua Xu. Myosin Light Chain Kinase Facilitates Endocytosis of Synaptic vesicles at hippocampal neurons. Journal of  Neurochemistry. 2016, 138: 60–73.

  6. Yong Liu#, Xiao-Mei Wu#, Qian-Qian Luo, Suna Huang, Qing-Wu Qian Yang, Fa-Xiang Wang, Ya Ke and Zhong-Ming Qian. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. Journal of Cerebral Blood Flow and Metabolism. 2015, 35(10):1623-31.

  7. Xiaomei Wu, Jianyou Su, Lei Chen, Baodong Ma, Xiaosu Gu, Li Zhu. Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801. Cellular and Molecular Neurobiology. 2015, 35(7):943-52.

  8. Xiaomei Wu, Cheng Zhou, Fang Du, Yapeng Lu, Bin Peng, Lei Chen, Li Zhu. Ginkgolide B Preconditioning on Astrocytes Promotes Neuronal Survival in Ischemic Injury via Up-regulating Erythropoietin Secretion. Neurochemistry International. 2013, 62: 157-164.

  9. Xiao-Mei Wu, Zhong-ming Qian, Li Zhu, Fang Du, Wing-ho Yung, Qi Gong, Ya Ke. Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801. British Journal of Pharmacology. 2011, 164: 332–343.

  10. Xiaomei Wu, Zhongming Qian, Ya Ke, Fang Du, Li Zhu. Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis. Journal of Cellular and Molecular Medicine. 2009, 13: 4474-4483.