朱俐

发布者:陈静发布时间:2016-09-26浏览次数:45

        

朱俐,教授,博士生导师

南通大学研究生工作部部长、研究生院常务副院长、学科建设办公室主任。19886月获南京大学理学学士学位(生理学专业),19917月获苏州医学院医学硕士学位,19986月获南京大学理学博士学位,在美国新泽西州医科齿科大学麻醉系和纽约州立脑基础研究所从事博士后研究2年。中国生物化学与分子生物技术专业委员会副主任委员,江苏省生物化学与分子生物学学会第九、十届理事会副理事长,《中国生物化学与分子生物学学报》编辑委员会编委,国家自然科学基金委员会专家评审组成员。江苏省高校青蓝工程中青年学术带头人培养对象和南通市“226高层次人才培养工程中青年科学技术带头人。曾被江苏省教育工委授予江苏省高等学校优秀共产党员称号,获交通运输部吴福-振华交通教育优秀教师奖。近年主持并完成省厅级以上课题9项,其中国家自然科学基金6项,现主持在研国家自然科学基金1项,领导的“低氧生物医学”团队近年先后获国家自然科学基金12项。近10年先后获南通市科技进步二等奖(第一名)、江苏省卫生厅医学新技术引进奖二等奖(第二名)、上海医学科技奖三等(第三名),授权专利5项。近5年作为通讯作者发表SCI源期刊论文17篇。共培养硕士研究生50余人,博士研究生3人。


研究方向:

  1. 低氧对细胞铁代谢相关蛋白表达调控的影响;

  2. 药物诱导缺氧预适应的细胞内信号通路

  3. 靶向性抗肿瘤药物胞内信号通路研究。


代表性论文(含第一作者为研究生):

  1. Yapeng Lu, Wangwang Ding, Bo Wang, Lu Wang, Huiwen Kan, Xueting Wang, Dan Wang, Li Zhu *. Positive regulation of human PINK1 and Parkin gene expression by nuclear respiratory factor 1. Mitochondrion. 2020, 51: 22-29.

  2. Xueting Wang, Zhiran Zou, Zhihui Yang, Shan Jiang, Yapeng Lu, Dan Wang, Zhangji Dong, Sha Xu, Li Zhu*. HIF 1 inhibits STAR transcription and testosterone synthesis in murine Leydig cells. Journal of Molecular Endocrinology, 2019, 62(1):1-13.

  3. Xueting Wang, Liuhan Jin, Shan Jiang, Dan Wang, Yapeng Lu, Li Zhu*. Transcription regulation of NRF1 on StAR reduces testosterone synthesis in hypoxemic murine. Journal of Steroid Biochemistry and Molecular Biology. 2019,191:105370.

  4. Li YLu ALong MCui LChen ZZhu L*. Nitroimidazole derivative incorporated liposomes for hypoxia-triggered drug delivery and enhanced therapeutic efficacy in patient-derived tumor xenografts. Acta Biomater. 2019, 83:334-348. (第一作者:李怡,2014届毕业生)

  5. Yapeng Lu, Huiwen Kan, Ying Wang, Dan Wang, Xueting Wang, Jing Gao*, Li Zhu*. Asiatic acid ameliorates hepatic ischemia/reperfusion injury in rats via mitochondria-targeted protective mechanism, Toxicology and applied pharmacology, 2018 (338): 214-223.

  6. Yang Lei, Wang Dan, Wang Xue Ting, Li Zhu*. The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia. Biochemical and Biophysical Research Communications, 2018. 507:128-135. (第一作者:杨磊,2019届毕业生)

  7. Dan Wang, Jie Zhang, Yapeng  Lu, Qianqian Luo, Li Zhu*. Nuclear respiratory factor-1 (NRF-1) regulated hypoxia-inducible factor-1 (HIF-1) under hypoxia in HEK293T, IUBMB Life. 2016, 68(9):748-755.

  8. Xueting Wang, Jie Ding, Zou Xiang, Peipei Jiang, Jing Du and Xiaodong Han. Microcystin-LR causes sexual hormone disturbance in male rat by targeting gonadotropin-releasing hormone neurons. Toxicon. 2016(123): 45-55.

  9. Lu Yapeng; Liu Siyuan; Wang Dang; Wang Ying; Gao Jing*; Zhu Li*; Asiatic acid uncouples respiration in isolated mouse liver mitochondria and induces HepG2 cells death. European journal of pharmacology. 2016 (786): 212-223.

  10. Lu Yapeng; Wang Bo; Shi Qian; Wang Xueting; Wang Dang; Zhu Li*; Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells. Scientific reports, 2016 (6): 39123.

  11. Xiaomei Wu, Jianyou Su, Lei Chen, Baodong Ma, Xiaosu Gu, Li Zhu*. Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801. Cell Mol Neurobiol. 2015, 35(7):943-52.

  12. Yapeng Lu, Rui Zhang, Siyuan Liu, Yu Zhao, Jing Gao, Li Zhu*. ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells. European Journal of Pharmacology. 2015(771):130-138.

  13. Chun-Ming Cheng , Dan Wang , Xian Cao, Qian-Qian Luo, Ya-Peng Lu, Li Zhu*. Iron regulatory protein 1 suppresses hypoxia-induced iron uptake proteins expression and decreases iron levels in HepG2 cells. Journal of Cellular Biochemistry. 2015, 116(9): 1919-1931.(第一作者:成春明,2013届毕业生)

  14. Yanfei Yang,Tingting Chen, Shajun Zhu, Xuefang Gu, Xueping Jia,Yapeng Lu, Li Zhu*.Two macrocyclic polyamines as modulators of metal –mediated Ab40 aggregation. Integrative Biology. 2015,7:655-662.(第一作者:杨燕飞,2013届毕业生)

  15. Wang F, Chen L, Zhang R, Chen Z, Zhu L*. RGD peptide conjugated liposomal drug delivery system for enhance therapeutic efficacy in treating bone metastasis from prostate cancer. Journal of Controlled Release  2014, 196: 222-233. (第一作者:王芳芳,2015届毕业生)